From the journal:

Organic & Biomolecular Chemistry

A new H2Se-selective fluorescent probe based on nitro reduction

Wenfang Liang,†b   Liyue Wang,†a   Zhili Yu,c   Wanxue Xu,d   Yalun Dong,b   Long Yi ORCID logo *b  and  Lu Sun ORCID logo *a  

* Corresponding authors

a Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China
E-mail: sunlu@tmu.edu.cn

b College of Chemical Engineering, Beijing University of Chemical Technology (BUCT), Beijing 100029, China
E-mail: yilong@mail.buct.edu.cn

c Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China

d Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China

Abstract

Hydrogen selenide (H2Se) is an emerging bioactive molecule associated with several physiological and pathological processes. To clarify the effects of H2Se in biological systems, the development of highly selective H2Se detection tools is essential. Herein, we rationally designed a series of potential H2Se probes based on nitroaromatic reduction followed by a self-immolative process and discovered a new H2Se detection platform (Nap-NO2-mCl). Nap-NO2-mCl exhibited high selectivity and sensitivity for H2Se, making it an effective tool for monitoring triggered-release H2Se and exogenous H2Se in living cells.

Graphical abstract: A new H2Se-selective fluorescent probe based on nitro reduction

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Article information

DOI
https://doi.org/10.1039/D5OB01386K
Article type
Communication
Submitted
27 Aug 2025
Accepted
29 Sep 2025
First published
29 Sep 2025

Org. Biomol. Chem., 2025, Advance Article

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A new H2Se-selective fluorescent probe based on nitro reduction

W. Liang, L. Wang, Z. Yu, W. Xu, Y. Dong, L. Yi and L. Sun, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB01386K

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