Enantioselective access to quaternary stereocenters of pyrrolidines via Rh-catalyzed intramolecular cyclization of 1,6-enynes

Abstract

We have developed an enantioselective Rh-catalyzed intramolecular cyclization of 1,6-enynes, efficiently yielding pyrrolidines with quaternary stereocenters. Substrates bearing terminal alkynes afforded diverse exocyclic pyrrolidines with excellent enantioselectivity (up to >97% ee), highlighting the superior stereocontrol and versatility of the chiral spiro diphosphine (SDP) ligand in this transformation.