An efficient synthesis of α,β,γ,γ-tetrasubstituted α,β-unsaturated γ-lactams has been developed through a tandem or one-pot oxidative Ritter reaction/Knoevenagel condensation of the functionalized nitriles and 2-arylketone for the first time.
Y. Chen, Y. Hu, Z. Gan, C. Yu, J. Mo, M. Chen, X. Zhang and F. Zhang, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB01300C
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