Nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides

Abstract

A nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides was realized by using manganese metal as the reducing agent. This protocol afforded a convenient approach for obtaining β-benzyl-substituted arylethylamines bearing various functional groups. The utility of this reaction was also demonstrated by their straightforward conversion to privileged tetrahydroisoquinoline derivatives.