One-Pot Three-Component Synthesis of Benzo[h]isoquinolin-3ones via Rhodium(III)-Catalyzed C-H Activation
Abstract
A Rh(III)-catalyzed one-pot synthesis of benzo[h]isoquinolin-3-ones from 1-naphthaldehyde, aniline and diazo compounds has been realized, with imine serving as the directing group which was generated through aldimine condensation in situ. This concise protocol features low dosage of catalyst, excellent yield of products, and a broad substrate scope.a)Blacquiere, 2022