One-Pot Three-Component Synthesis of Benzo[h]isoquinolin-3ones via Rhodium(III)-Catalyzed C-H Activation

Abstract

A Rh(III)-catalyzed one-pot synthesis of benzo[h]isoquinolin-3-ones from 1-naphthaldehyde, aniline and diazo compounds has been realized, with imine serving as the directing group which was generated through aldimine condensation in situ. This concise protocol features low dosage of catalyst, excellent yield of products, and a broad substrate scope.a)Blacquiere, 2022

Supplementary files

Article information

Article type
Communication
Submitted
29 Jul 2025
Accepted
23 Sep 2025
First published
24 Sep 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

One-Pot Three-Component Synthesis of Benzo[h]isoquinolin-3ones via Rhodium(III)-Catalyzed C-H Activation

W. Song, X. Jiang, W. G. Yu and Z. Xiang, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB01222H

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