Dimethyl(methylthio)sulfonium Salt Triggered Dithiocarbamation of Alkenes with CS2 and Amines

Abstract

In this work, a straightforward and practical four-component reaction involving alkenes, CS2, amines, and dimethyl(methylthio)sulfonium trifluoromethanesulfonate (DMTSM) is reported. This reaction enables the convenient synthesis of various S-alkyl dithiocarbamates in good to excellent yields. The mild reaction conditions, readily available starting materials and operational simplicity, along with numerous examples of late-stage functionalization, render this method highly attractive for organic synthesis.

Supplementary files

Article information

Article type
Paper
Submitted
26 Jun 2025
Accepted
04 Aug 2025
First published
04 Aug 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

Dimethyl(methylthio)sulfonium Salt Triggered Dithiocarbamation of Alkenes with CS2 and Amines

S. Peng, C. Qi, L. Duan, D. Luo, L. Cheng, S. Tian, L. Yang and L. Xie, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB01043H

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