Asymmetric synthesis and biological evaluation of ottensinin and its analogues

Abstract

The asymmetric synthesis of ottensinin, a rearranged labdane diterpene with a broad range of favourable bioactivities, has been realized based on fragment coupling of 16a and 13 in eight steps from (+)-sclareolide. This approach would enable the diverse synthesis of ottensinin analogues to facilitate future drug development based on ottensinin.