The reactivity of organoaluminum reagents with acyl cyanohydrins was studied using two methods for preparing the nucleophilic species. Mild and chemoselective conditions were developed and the unprecedented double addition of dimethylalkynylaluminums onto nitriles provided access to a wide range of substituted diethynyl carbinamines in good to excellent yields (>20 examples).
M. Pearson-Long, P. Bertus, F. Boeda and H. G. Nguyen, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00911A
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