Assembly of 1,3-Diaryl-1H-pyrazoles via Base-Mediated [3+2] cycloaddition

Abstract

1,3-Diaryl-1H-pyrazoles, serving as privileged heterocyclic scaffolds, demonstrate significant application potential in pharmaceutical development, functional materials, and agrochemical industries. This study presents a synthetic strategy based on [3+2] cycloaddition, achieving efficient construction of 1,3-Diaryl-1H-pyrazoles. A novel transition metal-free protocol was established through base-catalyzed intermolecular annulation of hydrazone with vinyl sulfoxides, followed by oxidation. The reaction system exhibited excellent substrate generality and demonstrated successful gram-scale synthesis. Subsequent investigations into synthetic applications further confirmed the methodology's practicality and scalability.

Supplementary files

Article information

Article type
Communication
Submitted
30 May 2025
Accepted
14 Jul 2025
First published
18 Jul 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

Assembly of 1,3-Diaryl-1H-pyrazoles via Base-Mediated [3+2] cycloaddition

T. Xu, Z. Zhong, J. Yan, Y. Chen, A. Wang and M. Wang, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00907C

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