Synthesis of benzo[d,e]quinoline-spiro-succinimides via rhodium-catalyzed C–H activation/annulation of 1-naphthylamides with maleimides†
Raj Naresh
Patel, 
ab
Dharmik Mahendra
Patel,
ab
Dinesh Gopichand
Thakur,
ab
Nileshkumar B
Rathod,
ab
Sachinkumar D.
Patel,
ab
Mahesh A.
Sonawane
ab
and
Subhash Chandra
Ghosh
*ab
ab
Dharmik Mahendra
Patel,
ab
Dinesh Gopichand
Thakur,
ab
Nileshkumar B
Rathod,
ab
Sachinkumar D.
Patel,
ab
Mahesh A.
Sonawane
ab
and
Subhash Chandra
Ghosh
*ab
Abstract
This study unveils the first rhodium-catalyzed synthesis of benzo[d,e]quinoline-spiro-succinimides via C–H activation/annulation of 1-naphthylamides with maleimides, utilizing picolinamide as a directing group. This method boasts a broad substrate scope, excellent yields, and wide range of functional group tolerance. Mechanistic insights and promising photoluminescence are reported, demonstrating an efficient route to valuable all-carbon quaternary spirocyclic compounds.
![Graphical abstract: Synthesis of benzo[d,e]quinoline-spiro-succinimides via rhodium-catalyzed C–H activation/annulation of 1-naphthylamides with maleimides](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D5OB00825E&imageInfo.ImageIdentifier.Year=2025)
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