Ni-Catalyzed intramolecular cyclization of Baylis–Hillman adducts of 2-cyanoaniline towards 2,3-dihydroquinolin-4(1H)-ones†
Abstract
A Ni-catalyzed reductive cyclization of Baylis–Hillman adducts of 2-cyanoaniline is presented. A novel class of quinolin-4-ones containing a quaternary carbon center were synthesized in moderate to good yields. With iPr-PyBOX as a chiral ligand, the catalytic enantioselective cyclization gave a moderate yield and ee.