Ni-Catalyzed Intramolecular Cyclization of 2-Cyanoaniline B-H Adducts towards 2,3-Dihydroquinolin-4(1H)-ones

Abstract

The Ni-catalyzed reductive cyclization of 2-cyanoaniline B-H adducts is unprecedentedly presented. A novel class of quinolin-4-ones containing a quaternary carbon center were synthesized in moderate to good yields. With iPr-PyBOX as chiral ligand, the catalytic enantioselective cyclization gave moderate yield and ee.