From the journal:

Organic & Biomolecular Chemistry

Synthesis of α-trifluoromethoxy-sulfide through the Pummerer rearrangement†

Mingxin Zhao,a   Ziyang Zhoua  and  Pingping Tang ORCID logo *a  

* Corresponding authors

a State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry Nankai University, Tianjin 300071, China
E-mail: ptang@nankai.edu.cn

Abstract

A novel synthetic protocol for α-trifluoromethoxy sulfides was developed, characterized by mild reaction conditions and excellent substrate compatibility, which could be successfully employed for late-stage fluorination of pharmaceutically active molecules.

Graphical abstract: Synthesis of α-trifluoromethoxy-sulfide through the Pummerer rearrangement

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Article information

DOI
https://doi.org/10.1039/D5OB00673B
Article type
Communication
Submitted
25 Apr 2025
Accepted
29 May 2025
First published
30 May 2025

Org. Biomol. Chem., 2025, Advance Article

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Synthesis of α-trifluoromethoxy-sulfide through the Pummerer rearrangement

M. Zhao, Z. Zhou and P. Tang, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB00673B

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