One-Pot Synthesis of Ferrocenyl-Substituted Allylamine Derivatives by Three-Component Reaction of α-(hydroxy) Alkyl Ferrocenes, Aldehydes and Secondary Amines

Abstract

We report an efficient one-pot three-component synthesis of ferrocenyl-substituted allylamine derivatives with α-(hydroxy) alkyl ferrocenes, aldehydes and amines. The advantages of this method are catalyst-free, wide substrate scope, simple experimental procedure and mild reaction condition. The origin of one-pot synthesis of ferrocenyl-substituted allylamine derivatives were explored through density functional theory calculations.