One-Pot Synthesis of Ferrocenyl-Substituted Allylamine Derivatives by Three-Component Reaction of α-(hydroxy) Alkyl Ferrocenes, Aldehydes and Secondary Amines

Abstract

We report an efficient one-pot three-component synthesis of ferrocenyl-substituted allylamine derivatives with α-(hydroxy) alkyl ferrocenes, aldehydes and amines. The advantages of this method are catalyst-free, wide substrate scope, simple experimental procedure and mild reaction condition. The origin of one-pot synthesis of ferrocenyl-substituted allylamine derivatives were explored through density functional theory calculations.

Supplementary files

Article information

Article type
Paper
Submitted
21 Apr 2025
Accepted
02 Jul 2025
First published
02 Jul 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

One-Pot Synthesis of Ferrocenyl-Substituted Allylamine Derivatives by Three-Component Reaction of α-(hydroxy) Alkyl Ferrocenes, Aldehydes and Secondary Amines

H. Yang, J. Zheng, H. Yuan, M. Zhang, W. ZHang, Z. Wang, J. He, Y. Ouyang, Y. Fan, Y. Huang and Q. Zhao, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00652J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements