One-pot synthesis of ferrocenyl-substituted allylamine derivatives by a three-component reaction of α-(hydroxy) alkyl ferrocenes, aldehydes and secondary amines

Abstract

We report an efficient one-pot, three-component synthesis of ferrocenyl-substituted allylamine derivatives with α-(hydroxy) alkyl ferrocenes, aldehydes and amines. The advantages of this method are its catalyst-free nature, broad substrate scope, operational simplicity and mild reaction conditions. The origin of this one-pot synthesis of ferrocenyl-substituted allylamine derivatives was explored through density functional theory calculations.

Graphical abstract: One-pot synthesis of ferrocenyl-substituted allylamine derivatives by a three-component reaction of α-(hydroxy) alkyl ferrocenes, aldehydes and secondary amines

Supplementary files

Article information

Article type
Paper
Submitted
21 Apr 2025
Accepted
02 Jul 2025
First published
02 Jul 2025

Org. Biomol. Chem., 2025, Advance Article

One-pot synthesis of ferrocenyl-substituted allylamine derivatives by a three-component reaction of α-(hydroxy) alkyl ferrocenes, aldehydes and secondary amines

H. Yang, J. Zheng, H. Yuan, M. Zhang, W. Zhang, Z. Wang, J. He, Y. Ouyang, Y. Fan, Y. Huang and Q. Zhao, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB00652J

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