Decatungstate-catalyzed α-C(sp3)–H functionalization of amides with para-quinone methides

Abstract

An efficient photocatalytic strategy for the synthesis of N-methylformamide-modified diarylmethane scaffolds that involves the 1,6-conjugate addition of a para-quinone methide to amides via a tetrabutylammonium-decatungstate-catalyzed hydrogen atom transfer process has been described. This protocol features mild conditions, operational ease, and good-to-excellent yields (up to 92%), and is broadly compatible with a variety of functional groups.