Issue 21, 2025

Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions

Abstract

In this work, we demonstrate the synthesis of a variety of 2,5-disubstituted 1,3,4-thiadiazoles in 28–85% yields via three-component cyclization of 2-methylquinolines, arylhydrazides, and S powder under metal-free conditions. This approach stands out due to its broad substrate scope, excellent functional group tolerance, additive-free nature, base-free nature, easy operation, and simple reaction system. This work offers a simple, concise, and convenient pathway for the assembly of a variety of 1,3,4-thiadiazoles, which is complementary to previous methods.

Graphical abstract: Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions

Supplementary files

Article information

Article type
Communication
Submitted
03 Apr 2025
Accepted
24 Apr 2025
First published
25 Apr 2025

Org. Biomol. Chem., 2025,23, 5101-5105

Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions

C. Chu, Y. Liu, M. Mao, D. Wang, J. Liu, H. Wei, M. Yu and J. Cai, Org. Biomol. Chem., 2025, 23, 5101 DOI: 10.1039/D5OB00554J

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