Visible light-promoted cascade synthesis of pyrazolidinones via N-aryl glycine and azomethine imines

Abstract

We present an effective, visible light-driven method for the synthesis of N-(β-amino)pyrazolidin-3-ones from N-aryl glycine and azomethine imines. This additive-free protocol utilizes blue light (λ_max = 435–445 nm) at room temperature, enabling a radical-mediated cascade reaction that delivers a diverse range of pyrazolidinones in yields up to 99%. The mild conditions, high efficiency, and broad substrate scope of this process make it an attractive strategy for streamlined synthesis in drug discovery and material science.