A protocol for selective synthesis of thiol-functionalized allylic sulfonyl fluorides

Abstract

An efficient and transition metal-free method has been established for synthesizing a class of novel thiol-functionalized allylic sulfonyl fluorides with exclusive regioselectivity. This method is distinguished by its broad functional group compatibility with up to 99% yield and mild reaction conditions. Additionally, subsequent SuFEx reactions and oxidation processes generated sulfonate, sulfoxide, and sulfone derivatives, which are key motifs in medicinal chemistry, with exceptional efficiency.