Rhodium-catalyzed isomerization of homoallylic alcohols with a tethered carbonyl group: pathway to 1,6-diketones

Abstract

Herein, we report a rhodium-catalyzed isomerization of homoallylic alcohols with a tethered carbonyl group to synthesize structurally diverse unsymmetrical 1,6-diketones with atom, step, and redox economy. By introducing chiral ligands, good enantioselective isomerization products can be obtained. The utility of this reaction was also demonstrated with diverse transformations.