Issue 20, 2025
From the journal:

Organic & Biomolecular Chemistry

Claisen rearrangement enabled efficient access to biaryl phenols†

Ke Yu,a   Tongxiang Cao ORCID logo *a  and  Shifa Zhu ORCID logo *a  

* Corresponding authors

a Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China
E-mail: caotx@scut.edu.cn, zhusf@scut.edu.cn

Abstract

A rapid method for C2-arylation of hydroxypyranone systems via a reductive iodonio-Claisen rearrangement (RICR) of λ3-iodanes is reported. By integrating the rearrangement products with a tandem Claisen reaction, a series of otherwise inaccessible biaryl phenols were efficiently synthesized.

Graphical abstract: Claisen rearrangement enabled efficient access to biaryl phenols

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Article information

DOI
https://doi.org/10.1039/D5OB00468C
Article type
Communication
Submitted
17 Mar 2025
Accepted
16 Apr 2025
First published
17 Apr 2025

Org. Biomol. Chem., 2025,23, 4879-4883

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Claisen rearrangement enabled efficient access to biaryl phenols

K. Yu, T. Cao and S. Zhu, Org. Biomol. Chem., 2025, 23, 4879 DOI: 10.1039/D5OB00468C

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