Novel indolespiro bicoumarins: synthesis and their antifungal activity

Abstract

This article reports a spiro cyclic system that contains an oxoindole and two coumarin rings. Dozens of compounds with such structure have been synthesized via a facile three-component reaction of isatin and 4-aminocoumarins, with yields up to 90%. The antifungal activity of these indolespiro[4H-pyrido[3,2-c][5,6-c]bicoumarins] has also been evaluated, and some of them showed good antifungal activity against Physalospora piricola.