Direct C–H fluorination/heteroarylation of oxindoles with quinoxalin-2(1H)-ones using Selectfluor

Abstract

Herein, we present an efficient and feasible strategy for direct C–H fluorination and heteroarylation of oxindoles on the C-3 position having a C(sp³)–H bond with quinoxalin-2(1H)-ones based on a radical coupling reaction via Selectfluor, a bifunctional reagent, as both the oxidant and fluorine source. This methodology provides a potential protocol to obtain 3-heteroaryl 3-fluorooxindoles in medium to excellent yields.