Alstoscholarisine M, a 6,7-seco-vallesamine monoterpenoid indole alkaloid with antimicrobial activity from Alstonia scholaris

Abstract

Alstoscholarisine M is a 6,7-seco-vallesamine monoterpenoid indole alkaloid with a rarely methylcarbamate fragment, isolated from the leaves of Alstonia scholaris. Extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction elucidated its structure. The fascinating compound exhibited potential antifungal activity against Trichophyton rubrum, and its activity was roughly comparable to the first-line antifungal drug griseofulvin and significantly more effective than berberine, an important antimicrobial drug originated from plants.

Supplementary files

Article information

Article type
Paper
Submitted
09 Mar 2025
Accepted
27 Mar 2025
First published
02 Apr 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

Alstoscholarisine M, a 6,7-seco-vallesamine monoterpenoid indole alkaloid with antimicrobial activity from Alstonia scholaris

H. F. Yu, L. C. Zhang, K. Mohamed, L. Li, J. Yao, Y. Liu, X. Li, C. Ding, R. Zhang and X. Luo, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00420A

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