TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3H)-ones from 2-aminobenzamides and isothiocyanates

Abstract

A practical protocol has been established to access 2-aminoquinazolin-4(3H)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates. The protocol allows for the formation of C−N bonds under mild conditions without metal catalysts or external oxidants. The practicability of this strategy is demonstrated by its broad substrate scope, good functional group compatibility, and Scale-up synthesis.