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A facile synthetic method for chiral aza-spirocyclic indanones was developed with excellent enantioselectivities (81%–98% ee) via rhodium-catalyzed asymmetric domino conjugate addition/1,4-Rh shift/nucleophilic addition with traditional substrates of conjugate addition. The factors that affected the selectivity for aza-spirocyclic indanones were systematically studied.

Graphical abstract: Highly enantio-selective synthesis of aza-spirocyclic indanones via rhodium catalysis

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