Cai-Lan Kou, Long Yang, Ling-Zhi Sun, Meng Li, Xi Luo, Hong-Bo Guo and Jian-Bo Xie
Org. Biomol. Chem., 2025,23, 3542-3546
DOI:
10.1039/D5OB00291E,
Communication
A facile synthetic method for chiral aza-spirocyclic indanones was developed with excellent enantioselectivities (81%–98% ee) via rhodium-catalyzed asymmetric domino conjugate addition/1,4-Rh shift/nucleophilic addition with traditional substrates of conjugate addition. The factors that affected the selectivity for aza-spirocyclic indanones were systematically studied.