Bismuth(iii)chloride catalyzed one-pot synthesis of thioenol ethers from 1,3-dicabonyls/2-oxindoles under ultrasonic irradiation

Abstract

An efficient one-pot, three-component strategy has been devised for the facile construction of thioenol ethers related to biologically potent scaffolds. This method employs β-ketoesters or 1,3-diones or 2-oxindole, N,N-dimethylformamide dimethylacetal (DMF-DMA), and thiols under BiCl₃-catalyzed, ultrasound-assisted conditions. This methodology's key features include readily accessible building blocks, a cost-effective and environmentally friendly catalytic system, solvent-free reaction conditions, shorter reaction times, broad substrate scope, and good isolated yields.