Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system†
Abstract
Herein we report the conjugate borylation of vinyl sulfones mediated by ion pairing, which enables the efficient synthesis of β-sulfonyl alcohols bearing diverse functionalities in 13–98% yields. Further mechanistic investigations suggest the formation of anionic boryl-copper intermediates that kinetically accelerate reactant transfer across phases and provide enhanced boryl nucleophilicity.