Issue 14, 2025

Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system

Abstract

Herein we report the conjugate borylation of vinyl sulfones mediated by ion pairing, which enables the efficient synthesis of β-sulfonyl alcohols bearing diverse functionalities in 13–98% yields. Further mechanistic investigations suggest the formation of anionic boryl-copper intermediates that kinetically accelerate reactant transfer across phases and provide enhanced boryl nucleophilicity.

Graphical abstract: Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system

Supplementary files

Article information

Article type
Communication
Submitted
11 Feb 2025
Accepted
11 Mar 2025
First published
17 Mar 2025

Org. Biomol. Chem., 2025,23, 3330-3335

Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system

S. Jiang, Y. Ge, A. Zhang, S. Hu, T. Jin, J. Chen, H. Zhang, Y. Qin, X. Ma, J. Tang and J. Liu, Org. Biomol. Chem., 2025, 23, 3330 DOI: 10.1039/D5OB00242G

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