Display selection of peptide ligands for helical aromatic foldamers

Lingfei Wang; Joseph M. Rogers; Simon J. Dawson; Line M. Langhorn; Ryan T. Howard; Sunbum Kwon; Céline Douat; Hiroaki Suga; Ivan Huc

doi:10.1039/D5OB00228A

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Display selection of peptide ligands for helical aromatic foldamers†

Lingfei Wang,^a Joseph M. Rogers,

‡^b Simon J. Dawson,^c Line M. Langhorn,^a Ryan T. Howard,^a Sunbum Kwon,

§^a Céline Douat,

*^a Hiroaki Suga

*^b and Ivan Huc

*^ac

Author affiliations

* Corresponding authors

^a Department Pharmazie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany
E-mail: celine.douat@cup.lmu.de, ivan.huc@cup.lmu.de

^b Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, Japan
E-mail: hsuga@chem.s.u-tokyo.ac.jp

^c CBMN (UMR5248), Univ. Bordeaux-CNRS-INP, Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33600 Pessac, France

Abstract

Helical aromatic oligoamide foldamers with a cluster of five biogenic side chains at their surface were designed and synthesized. Display selection of thioether macrocyclic peptides against these targets generated low micromolar binders that are highly selective for the side-chain arrangement.

This article is part of the themed collection: Foldamers

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Article information

DOI: https://doi.org/10.1039/D5OB00228A
Article type: Communication
Submitted: 09 Feb 2025
Accepted: 03 Apr 2025
First published: 03 Apr 2025
This article is Open Access

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Org. Biomol. Chem., 2025,23, 4641-4647

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Display selection of peptide ligands for helical aromatic foldamers

L. Wang, J. M. Rogers, S. J. Dawson, L. M. Langhorn, R. T. Howard, S. Kwon, C. Douat, H. Suga and I. Huc, Org. Biomol. Chem., 2025, 23, 4641 DOI: 10.1039/D5OB00228A

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Organic & Biomolecular Chemistry

Display selection of peptide ligands for helical aromatic foldamers†

Abstract

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Display selection of peptide ligands for helical aromatic foldamers

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