Highly regio- and stereo-controlled synthesis of (Z)-4-(trifluoromethyl)-3-(phenylthio)-1-substituted-but-3-en-1-ynes via hydroalkynylation of alkynyl thioethers

Abstract

The palladium-catalyzed addition of terminal acetylenes to 1-(trifluoromethyl)-2-(phenylthiol)ethyne, generated in situ, proceeded readily to afford the corresponding (Z)-4-(trifluoromethyl)-3-(phenylthio)-1-substituted-but-3-en-1-ynes in good to high yields with excellent regio- and stereocontrol under mild conditions.