An I2/amine synergistic catalysis enables 2,2′-bipyridine synthesis from oxime esters and enals

Abstract

A synergistic I₂/secondary amine catalysis has been developed for the modular assembly of 2,2′-bipyridines, employing oxime esters and enals as readily available starting materials. This method demonstrates a good substrate scope and functional group tolerance and can easily afford a series of structurally new 2,2′-bipyridines in moderate to good yields.