Reagent-assisted regio-divergent cyclization synthesis of pyrazole

Abstract

The present study reveals a practical one-pot base-promoted regio-divergent cyclization of hydrazines with alkynyl silane under mild conditions, facilitating the synthesis of diverse silicone-substituted pyrazoles and functionalized pyrazoles in great yields with exceptional selectivity. This protocol is expected to afford a streamlined one-pot approach for the synthesis of multiple compounds in water.