Pd-catalyzed asymmetric etherification of 2H-chromenes: enantioselective construction of chiral 4-alkoxy-4H-chromenes

Abstract

A new strategy for the construction of a chiral 4-alkoxy-4H-chromene skeleton was reported. A series of chiral 4-alkoxy-4H-chromenes containing the trifluoromethyl group were obtained in good yields (up to 80% yield) and excellent enantioselectivity (up to 93% ee).