Issue 21, 2025

Chemoselective benzylic Csp3–H bond oxidation reactions catalyzed by the AgII(bipy)2S2O8 complex

Abstract

Herein, we present a silver-catalyzed method for the selective oxidation of benzylic Csp3–H bonds with high chemo- and regioselectivity. This approach efficiently converts toluenes into aldehydes, benzylic methylenes into ketones, and benzylic alcohols into aldehydes. Notably, the reaction also proceeds under in situ generated catalytic conditions and is scalable. Control experiments further indicate that water serves as the oxygen source in the oxidized products.

Graphical abstract: Chemoselective benzylic Csp3–H bond oxidation reactions catalyzed by the AgII(bipy)2S2O8 complex

Supplementary files

Article information

Article type
Paper
Submitted
23 Dec 2024
Accepted
16 Apr 2025
First published
28 Apr 2025

Org. Biomol. Chem., 2025,23, 5224-5233

Chemoselective benzylic Csp3–H bond oxidation reactions catalyzed by the AgII(bipy)2S2O8 complex

Z. Akhter, S. Sharma, R. Anand, M. Samad, P. K. Verma and P. P. Singh, Org. Biomol. Chem., 2025, 23, 5224 DOI: 10.1039/D4OB02074J

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