Racemic assembly of minimalistic heterochiral tripeptides boosts their biocatalytic activity for ester hydrolysis. The amino acidic sequences are bioinspired and feature histidine (His) as a catalytically active residue, and the diphenylalanine (Phe-Phe) motif to drive self-assembly into anisotropic nanostructures that gel. This study thus provides key insights for the design of green biocatalysts with improved activity.
M. C. Mañas-Torres, P. Alletto, S. Adorinni, A. V. Vargiu, L. Álvarez de Cienfuegos and S. Marchesan, Org. Biomol. Chem., 2025, 23, 2797 DOI: 10.1039/D4OB01987C
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