Advances in the selective functionalization of B(3,6)–H of o-carboranes

Abstract

This review summarizes the methodologies for the selective functionalization of the B(3,6) vertices of o-carboranes, including the deboration-capitation reaction, the coupling reaction of B–X (X = I, Br) bonds, reactions of 1,3-dehydro-o-carborane and [3-N₂-o-C₂B₁₀H₁₁][BF₄] as well as transition-metal-catalyzed B–H activation. These works offer a versatile toolbox for synthesizing B(3,6)-substituted o-carborane derivatives and will promote their applications in material science, pharmaceutical chemistry, and related disciplines.