Issue 4, 2025

Concise total synthesis of (±)-applanatumol Y

Abstract

Total synthesis of (±)-applanatumol Y was achieved in 5 steps, featuring a cascade annulation including Michael addition, aldol condensation, and oxy-Michael addition reactions, all promoted by DBU. This approach offers a streamlined and cost-effective route for constructing complex tricyclic frameworks under mild and metal-free conditions.

Graphical abstract: Concise total synthesis of (±)-applanatumol Y

Supplementary files

Article information

Article type
Communication
Submitted
02 Nov 2024
Accepted
04 Dec 2024
First published
04 Dec 2024

Org. Biomol. Chem., 2025,23, 814-816

Concise total synthesis of (±)-applanatumol Y

W. Yuan, L. Jin, S. Luo, M. Yuan, Z. Cai and H. Qin, Org. Biomol. Chem., 2025, 23, 814 DOI: 10.1039/D4OB01763C

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