Issue 9, 2025

I2-Catalyzed benzylation of NH-sulfoximines with diarylmethanes and alkylarenes

Abstract

A practical transition metal-free approach for the selective benzylation of NH-sulfoximines has been disclosed by using simple elemental iodine as the catalyst and tert-butyl hydroperoxide (TBHP) as the terminal oxidant. Comparing with known methods for the construction of N-benzylated sulfoximines, our protocol shows broad substrate scope with respect to both diarylmethanes and alkylarenes, and can be conducted in air with good functional group tolerance.

Graphical abstract: I2-Catalyzed benzylation of NH-sulfoximines with diarylmethanes and alkylarenes

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Article information

Article type
Communication
Submitted
24 Oct 2024
Accepted
15 Jan 2025
First published
16 Jan 2025

Org. Biomol. Chem., 2025,23, 2111-2114

I2-Catalyzed benzylation of NH-sulfoximines with diarylmethanes and alkylarenes

Y. Chen, Q. Chen, S. Zhang, K. Feng, X. Kong, X. Chen, W. Li and Z. Cao, Org. Biomol. Chem., 2025, 23, 2111 DOI: 10.1039/D4OB01709A

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