Electrochemical synthesis of γ-carbolinones via sulfonylation-triggered cyclization of indole-3-carboxamides

Abstract

A novel electrochemical radical cyclization reaction of N-acryloyl-indole-3-carboxamides with sodium sulfinates as coupling partners has been developed, which delivers multi-substituted γ-carbolinones as products with up to 70% yields. This study represents the first example of the radical cyclization reaction of indole-3-carboxamides under electrochemical conditions. The reaction features a broad substrate scope of sodium sulfinates and indole-3-carboxamides, and provides a new and efficient strategy for the synthesis of γ-carbolinone derivatives.