Microwave-assisted [3 + 2] cycloaddition reactions of dicyanoepoxides with benzylidene Meldrum's acids†
Yazdanbakhsh
Lotfi Nosood, 
*a
Ahmad
Takallou,
a
Ali
Rostami,
a
Muhammad U.
Anwar
a
and
Ahmed
Al-Harrasi
*a
*a
Ahmad
Takallou,
a
Ali
Rostami,
a
Muhammad U.
Anwar
a
and
Ahmed
Al-Harrasi
*a
Abstract
The [3 + 2] cycloaddition of dicyanoepoxides with benzylidene Meldrum's acid under microwave irradiation and solvent-free conditions was explored for the synthesis of trioxaspirodecanes. This method presents a highly diastereo- and regioselective route to spiro cycloadducts, delivering similar stereoselectivity to conventional reflux in toluene but with shorter reaction times and improved yields.
![Graphical abstract: Microwave-assisted [3 + 2] cycloaddition reactions of dicyanoepoxides with benzylidene Meldrum's acids](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D4OB01702A&imageInfo.ImageIdentifier.Year=2025)
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