Total syntheses of Kavaratamide A and 5-epi-Kavaratamide A

Abstract

The total synthesis of Kavaratamide A, a new Linear Lipodepsipeptide from the Marine Cyanobacterium Moorena bouillonii was achieved by assembling the side chain in stage through condensation coupling, carbon-chain extension, Steglich esterification and Evans aldol reaction. In addition, total synthesis of Kavaratamide A's isomer, 5-epi-kavaratamide A, is also successfully achieved. Cytotoxicity test suggested that Kavaratamide A and 5-epi-Kavaratamide A have a moderate bioactivity against cancer cells.