Design of Colloidal Vectors for Active Targeting via Complexation of Biotinylated Copolymers with Gadolinium Ions

Abstract

This study presents the design of biotin-functionalized hybrid polyionic complexes (HPICs) using RAFT polymers for targeted MRI applications. The synthesized colloidal vectors, complexed with gadolinium ions, demonstrate high stability, relaxivity, and biotin accessibility for active targeting. Preliminary in vivo studies confirm their potential for improved MRI contrast and pharmacokinetic tracking.