Issue 28, 2025
From the journal:

Nanoscale

MINFLUX: μs and nm precision 3D tracking of dynamic lipid mobility on nanoparticles†

Laurence W. Fitzpatrick,a   Laura Woythe,a   Ziqiang Huang,b   Sebastian Schnorrenberg,b   Timo Zimmermannb  and  Lorenzo Albertazzi ORCID logo *a  

* Corresponding authors

a Department of Biomedical Engineering, Institute of Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands
E-mail: L.albertazzi@tue.nl

b EMBL Imaging Centre, EMBL, Heidelberg, Germany

Abstract

MINFLUX microscopy opened unique opportunities to investigate complex molecular systems at a single molecule level with μs temporal and nm spatial resolutions in 3D. Here, we demonstrate its use for the characterization of nanomaterials, providing a framework for MINFLUX imaging and data analysis tailored to understanding the complex dynamics of nanosized Silica-Supported Lipid Bilayers (SSLBs).

Graphical abstract: MINFLUX: μs and nm precision 3D tracking of dynamic lipid mobility on nanoparticles

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Article information

DOI
https://doi.org/10.1039/D5NR00948K
Article type
Communication
Submitted
04 Mar 2025
Accepted
29 Jun 2025
First published
02 Jul 2025
This article is Open Access
Creative Commons BY license

Nanoscale, 2025,17, 16609-16615

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MINFLUX: μs and nm precision 3D tracking of dynamic lipid mobility on nanoparticles

L. W. Fitzpatrick, L. Woythe, Z. Huang, S. Schnorrenberg, T. Zimmermann and L. Albertazzi, Nanoscale, 2025, 17, 16609 DOI: 10.1039/D5NR00948K

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