An optical/magnetic imaging nanoplatform-mediated convection-enhanced delivery of oxaliplatin for glioma treatment

Abstract

Glioma is a highly lethal form of cancer, and its treatment requires overcoming several challenges, including the blood–brain barrier (BBB), rapid drug release at the tumor site, and monitoring of drug distribution. Herein, we have developed a bio-responsive optical/magnetic signal amplification nanoplatform (Gd/Cy5-Oxa@NPs) by conjugating a pH-responsive polymer block copolymer with cyanine 5 dye and then loaded this with gadolinium chloride and oxaliplatin (Oxa). The nanoplatform is administered via convection-enhanced delivery (CED) to hinder the progression of glioblastoma tumors. The CED of the nanoplatform offers a direct way to bypass the BBB, significantly reducing the required dosage without inducing detectable toxicity. The nanoplatform facilitates cell internalization and rapidly releases Oxa in acidic environments, enhancing treatment accuracy. In vivo experimental results demonstrate that the nanoplatform achieves remarkable anti-glioma efficacy through CED at low concentrations. Our research suggests that the combination of a pH-responsive optical/magnetic imaging nanoplatform and CED may represent a promising translational strategy for drug tracking and glioma treatment.