Issue 12, 2025
From the journal:

Nanoscale

Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus Aspergillus fumigatus†

Yidong Yu, ORCID logo ‡ab   Theresa Vogel,‡c   Sina Hirsch,a   Jürgen Groll,c   Krystyna Albrecht*c  and  Andreas Beilhack*a  

* Corresponding authors

a Department of Internal Medicine II, Center for Experimental Molecular Medicine, Würzburg University Hospital, 97078 Würzburg, Germany
E-mail: beilhack_a@ukw.de

b JSPS International Research Fellow, Endowed Course “Drug Discoveries by Silkworm Models”, Faculty of Pharmaceutical Sciences, Teikyo University, 192-0395 Tokyo, Japan

c Department for Functional Materials in Medicine and Dentistry, Institute of Functional Materials and Biofabrication, University of Würzburg, 97070 Würzburg, Germany
E-mail: Krystyna.albrecht@uni-wuerzburg.de

Abstract

We developed siRNA-loaded anionic liposomes, co-encapsulating low-dose amphotericin B, to enhance siRNA penetration through the fungal cell wall of Aspergillus fumigatus. Targeting mRNAs of three key genes, these liposomes visibly inhibited fungal growth, demonstrating for the first time the antifungal potential of siRNA against human fungal pathogens.

Graphical abstract: Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus Aspergillus fumigatus

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D4NR03225J
Article type
Communication
Submitted
06 Aug 2024
Accepted
13 Oct 2024
First published
07 Nov 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2025,17, 7002-7007

Permissions

Request permissions

Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus Aspergillus fumigatus

Y. Yu, T. Vogel, S. Hirsch, J. Groll, K. Albrecht and A. Beilhack, Nanoscale, 2025, 17, 7002 DOI: 10.1039/D4NR03225J

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements