Tetralone embedded Schiff base organosilane for the detection of Al (III): in-silico and its anticancer activity

Abstract

The article presents the synthesis of chemosensor 3a based on tetralone functionalised Schiff base linked organosilane via condensation reaction. The synthesized ligand 3a is well characterised by via FT-IR, NMR spectroscopy and mass spectrometry. The 3a has high selectivity and sensitivity towards Al (III) ions compared to other metal ions . The binding of 3a with Al (III) is confirmed by using Stern Volmer equation. The Limit of detection (LOD) and binding constant (Ka) came out to be 2.78×10-8 M and 2.59×104M-1 respectively. It showed an excellent anticancer activity against Hela cells with decrease of a cell viability up to 58.89%. Molecular docking was also done against 4xr8 which confirmed the anticancer efficiency of 3a.