Cascade reaction of 2-bromo-2H-azirine-2-carboxylate with malonic esters: facile access to highly substituted pyrrolinones
Abstract
Highly substituted pyrrolinones were unexpectedly synthesized through a base-mediated reaction between a malonic ester and 2-bromo-2H-azirine-2-carboxylate. In this transformation, the azirine acted as a doubly electrophilic linchpin, undergoing cascade and ring-expansion processes to afford efficient access to pyrrolinones.