Cascade reaction of 2-bromo-2H-azirine-2-carboxylate with malonic esters: facile access to highly substituted pyrrolinones

Abstract

Highly substituted pyrrolinones were unexpectedly synthesized through a base-mediated reaction between a malonic ester and 2-bromo-2H-azirine-2-carboxylate. In this transformation, the azirine acted as a doubly electrophilic linchpin, undergoing cascade and ring-expansion processes to afford efficient access to pyrrolinones.

Supplementary files

Article information

Article type
Communication
Submitted
06 Jun 2025
Accepted
25 Aug 2025
First published
26 Aug 2025

New J. Chem., 2025, Accepted Manuscript

Cascade reaction of 2-bromo-2H-azirine-2-carboxylate with malonic esters: facile access to highly substituted pyrrolinones

P. Pradhan, S. S. A., J. B. Nanubolu and S. Gangarajula, New J. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5NJ02356D

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