Issue 28, 2025

Mitochondrial delivery of aggregation-induced emission active molecules via a micellar nanocarrier

Abstract

Mitochondrial delivery of aggregation-induced emission (AIE) active molecules is critical for their imaging/therapeutic applications. However, nanocarrier-based mitochondrial delivery via an endocytosis approach limits the targeting ability due to lysosomal entrapment. In this work, we report an amino acid-based polymer nanomicelle for mitochondrial delivery of small molecules within 5 minutes via a non-endocytic process that bypasses lysosomal trafficking. The nanocarrier facilitates direct membrane penetration and delivery of AIE molecules that enables mitochondria delivery without endosomal/lysosomal trapping. This approach may be extended to the mitochondrial-targeted therapeutic application of AIE molecules.

Graphical abstract: Mitochondrial delivery of aggregation-induced emission active molecules via a micellar nanocarrier

Supplementary files

Article information

Article type
Paper
Submitted
03 May 2025
Accepted
05 Jun 2025
First published
06 Jun 2025

New J. Chem., 2025,49, 12102-12108

Mitochondrial delivery of aggregation-induced emission active molecules via a micellar nanocarrier

K. Mandal, S. Shaw and N. R. Jana, New J. Chem., 2025, 49, 12102 DOI: 10.1039/D5NJ01876E

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