Anti-cancer potential of a new bioactive copper-based coordination polymer against cervical cancer

Abstract

Cervical cancer represents the most prevalent gynecological malignancy. The preferred treatment for advanced cervical cancer is platinum-containing drugs in combination with X-ray radiation therapy. However, this approach is associated with significant toxicity and a high recurrence rate. Therefore, the design and development of treatments with definite efficacy and low toxicity are the focus of research continuously explored by medical researchers. This study aimed to evaluate the anticancer potential of a new copper-based coordination polymer (Cu-CP) against cervical cancer cells. The experimental results demonstrated that Cu-CP exhibited dose-dependent proliferation inhibition in cervical cancer cells. Flow cytometry analysis revealed G2/M phase arrest; concurrently, apoptosis rates increased under the same conditions. Additionally, Cu-CP triggered the generation of reactive oxygen species (ROS), which disrupted cellular homeostasis and ultimately impaired cell viability. These findings highlight Cu-CP's dual anti-tumor mechanism involving the induction of cell cycle blockade, apoptosis, and oxidative stress. The findings of this study indicate that Cu-CP may be another metal compound, following platinum, that could prove effective in the treatment of cervical cancer.