Issue 21, 2025

ANRORC-type reactions of azolo[1,5-a]pyrimidine-6-carbonitriles with O- and N-nucleophiles

Abstract

Azolo[1,5-a]pyrimidines represent an important class of nitrogen-containing heterocycles due to a wide range of useful properties. In this work, we have investigated in detail the ANRORC-type reactions for aryl-azolo[1,5-a]pyrimidine-6-carbonitriles and their benzannelated analogs initiated by treatment with O- and N-nucleophiles. The reactivity of the starting azolopyrimidines was studied, and the proposed mechanisms were confirmed by DFT-calculations.

Graphical abstract: ANRORC-type reactions of azolo[1,5-a]pyrimidine-6-carbonitriles with O- and N-nucleophiles

Supplementary files

Article information

Article type
Communication
Submitted
18 Jan 2025
Accepted
07 May 2025
First published
15 May 2025

New J. Chem., 2025,49, 8627-8631

ANRORC-type reactions of azolo[1,5-a]pyrimidine-6-carbonitriles with O- and N-nucleophiles

S. V. Aminov, V. V. Fedotov, K. V. Savateev, A. O. Neymash, E. N. Ulomsky, P. A. Slepukhin and V. L. Rusinov, New J. Chem., 2025, 49, 8627 DOI: 10.1039/D5NJ00255A

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