Issue 16, 2025

Two-dimensional vanadium carbide (V2CTx) MXenes for one-pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles

Abstract

The development of new reusable and efficient heterogeneous catalysts for the construction of bioactive heterocyclic compounds is of great interest in the present era. Two-dimensional (2D) materials, especially 2D vanadium carbide (V2CTx MXene), are widely used in energy storage and conversion because of their good electronic properties and broad surface area, but 2D V2CTx MXene has not been explored as a catalyst support for organic transformation. Herein, we demonstrate a smooth cyclization reaction between aldehydes and hydrazides to construct 2,5-disubstituted-1,3,4-oxadiazoles catalyzed by 2D V2CTx MXenes. We were able to attach a wide range of substituents on the 2nd and 5th positions of the 1,3,4-oxadiazole ring. The present protocol showed broad functional group tolerance with product yields ranging from 84% to 93% in a shorter reaction time (30–45 min). The 2D V2CTx MXene catalyst was able to produce good yields of product even after five catalytic cycles.

Graphical abstract: Two-dimensional vanadium carbide (V2CTx) MXenes for one-pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles

Supplementary files

Article information

Article type
Communication
Submitted
01 Dec 2024
Accepted
26 Mar 2025
First published
28 Mar 2025

New J. Chem., 2025,49, 6517-6523

Two-dimensional vanadium carbide (V2CTx) MXenes for one-pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles

S. Raju, Y. R. Girish, M. S. Ali, H. A. Al-Lohedan, K. Pramoda and K. S. Sharath Kumar, New J. Chem., 2025, 49, 6517 DOI: 10.1039/D4NJ05159A

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